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Infection and Immunity, September 2003, p. 5360-5363, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5360-5363.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Evidence for a Melanin Cell Wall Component in Pneumocystis carinii

Crystal R. Icenhour,1 Theodore J. Kottom,1 and Andrew H. Limper1,2*

Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care and Internal Medicine,1 Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota 559052

Received 7 April 2003/ Returned for modification 3 May 2003/ Accepted 14 June 2003

Fluorescein isothiocyanate-labeled monoclonal antibodies specific for fungal melanin were used in this study to visualize melanin-like components of the Pneumocystis carinii cell wall. A colorimetric enzyme assay confirmed these findings. This is the first report of melanin-like pigments in Pneumocystis.

* Corresponding author. Mailing address: Mayo Clinic, 8-24 Stabile Building, Rochester, MN 55905. Phone: (507) 284-2964. Fax: (507) 284-4521. E-mail: Limper.Andrew{at}mayo.edu.

Editor: T. R. Kozel

Infection and Immunity, September 2003, p. 5360-5363, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5360-5363.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Icenhour, C. R., Kottom, T. J., Limper, A. H. (2006). Pneumocystis Melanins Confer Enhanced Organism Viability. Eukaryot Cell 5: 916-923 [Abstract] [Full Text]  


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