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Infection and Immunity, September 2003, p. 5376-5380, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5376-5380.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Intracellular Survival of Streptococcus pyogenes in Polymorphonuclear Cells Results in Increased Bacterial Virulence

Eva Medina,* Manfred Rohde, and Gursharan S. Chhatwal

Department of Microbial Pathogenesis and Vaccine Research, GBF-German Research Centre for Biotechnology, Braunschweig, Germany

Received 21 February 2003/ Returned for modification 27 March 2003/ Accepted 28 May 2003

It has recently been shown that survival within phagocytic cells constitutes an additional strategy used by Streptococcus pyogenes to evade the host defenses. Here we provide evidence that S. pyogenes can escape from the phagosome into the cytoplasm of phagocytic cells. Furthermore, intracellular bacteria seem to undergo phenotypic switching that results in much more virulent microorganisms.

* Corresponding author. Mailing address: Department of Microbial Pathogenesis and Vaccine Research, GBF-German Research Center for Biotechnology, Mascheroder Weg 1, D-38124 Braunschweig, Germany. Phone: 0531/6181466. Fax: 0531/6181708. E-mail: eme{at}gbf.de.

Editor: D. L. Burns

Infection and Immunity, September 2003, p. 5376-5380, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5376-5380.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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