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Infection and Immunity, September 2003, p. 5398-5401, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5398-5401.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Nicotinamide Ribosyl Uptake Mutants in Haemophilus influenzae

Mark Herbert,1* Elizabeta Sauer,2 Graeme Smethurst,1 Anita Kraiß,2 Anna-Karina Hilpert,2 and Joachim Reidl2

Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom,1 Zentrum für Infektionsforschung, Universität Würzburg, 97070 Würzburg, Germany2

Received 21 March 2003/ Returned for modification 16 May 2003/ Accepted 3 June 2003

The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus influenzae. A pnuC mutant had only residual NR uptake and could survive in vitro with high concentrations of NR, but could not survive in vivo. PnuC may represent a target for the development of inhibitors for preventing H. influenzae disease.

* Corresponding author. Mailing address: Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom. E-mail: mherbert{at}molbiol.ox.ac.uk.

Editor: J. T. Barbieri

Infection and Immunity, September 2003, p. 5398-5401, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5398-5401.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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