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Infection and Immunity, September 2003, p. 5402-5406, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5402-5406.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Genetic Variation Influences the B-Cell Response to Immunization with a Pneumococcal Polysaccharide Conjugate Vaccine

T. L. McCool,1,2,{dagger} J. R. Schreiber,1,2,3* and N. S. Greenspan1*

Departments of Pathology,1 Pediatrics, Case Western Reserve University,2 Divisions of Infectious Diseases, Allergy, Immunology, and Rheumatology, Rainbow Babies and Children's Hospital, Cleveland Ohio 441063

Received 28 March 2003/ Returned for modification 1 May 2003/ Accepted 27 May 2003

CBA/J mice immunized with pneumococcal 23F-CRM197 vaccine produce significantly lower titers of 23F-specific antibodies and fewer 23F-specific antibody-secreting cells (ASC) than did BALB/c or (CBA/J x BALB/c)F1 (CCBAF1) mice. The reduced 23F-specific titers of CBA/J versus BALB/c or CCBAF1 mice are presumably related to lower frequencies of 23F-specific ASC influenced by genetic variation.

* Corresponding author. Mailing address for N. S. Greenspan: Biomedical Research Building, Rm. 927, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106-4943. Phone: (216) 368-1280. Fax: (216) 368-1300. E-mail: nsg{at}po.cwru.edu. Mailing address for J. R. Schreiber: Department of Pediatrics, Case Western Reserve University, and Divisions of Pediatric Infectious Diseases, Allergy, Immunology, and Rheumatology, Rainbow Babies and Children’s Hospital, 11100 Euclid Ave., Cleveland, OH 44106. Phone: (216) 844-8735. Fax: (216) 844-8362. E-mail: jrs3{at}cwru.edu.

Editor: J. N. Weiser

{dagger} Present address: Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104.

Infection and Immunity, September 2003, p. 5402-5406, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5402-5406.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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