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Infection and Immunity, September 2003, p. 5412-5417, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5412-5417.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Induction of T Helper Type 1 Responses by a Polysaccharide Deacetylase from Cryptococcus neoformans

Carmelo Biondo, Concetta Beninati, Mauro Bombaci, Luciano Messina, Giuseppe Mancuso, Angelina Midiri, Roberta Galbo, and Giuseppe Teti*

Dipartimento di Patologia e Microbiologia Sperimentale, Facoltà di Medicina e Chirurgia, Università di Messina, I-98125 Messina, Italy

Received 13 December 2002/ Returned for modification 28 January 2003/ Accepted 23 June 2003

A 25-kDa cryptococcal deacetylase (d25) was found here to induce cell proliferation, as well as secretion of interleukin 2 and gamma interferon, but not interleukin 4, in spleen cells from d25-immunized or Cryptococcus neoformans-infected mice. The gamma interferon, but not the interleukin 2, response was required for the protective activities of d25 immunization in a murine cryptococcosis model.

* Corresponding author. Mailing address: Dipartimento di Patologia e Microbiologia Sperimentale, Policlinico Universitario, Via Consolare Valeria, 1 (Gazzi), I-98125 Messina, Italy. Phone: 39 090 221-3311. Fax: 39 090 221-3312. E-mail: teti{at}eniware.it.

Editor: T. R. Kozel

Infection and Immunity, September 2003, p. 5412-5417, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5412-5417.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Baker, L. G., Specht, C. A., Donlin, M. J., Lodge, J. K. (2007). Chitosan, the Deacetylated Form of Chitin, Is Necessary for Cell Wall Integrity in Cryptococcus neoformans. Eukaryot Cell 6: 855-867 [Abstract] [Full Text]  
  • Biondo, C., Messina, L., Bombaci, M., Mancuso, G., Midiri, A., Beninati, C., Cusumano, V., Gerace, E., Papasergi, S., Teti, G. (2005). Characterization of Two Novel Cryptococcal Mannoproteins Recognized by Immune Sera. Infect. Immun. 73: 7348-7355 [Abstract] [Full Text]  


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