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Infection and Immunity, September 2003, p. 5422-5426, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5422-5426.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Host Cell Fate on Cryptosporidium parvum Egress from MDCK Cells

David A. Elliott{dagger} and Douglas P. Clark*

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287

Received 9 January 2003/ Returned for modification / Accepted 25 June 2003

Cryptosporidium parvum is an intracellular protozoan parasite that causes a severe diarrheal illness of unclear etiology. Also unclear is the fate of the host cell upon parasite egress. We show in an MDCK cell model that the host cell is killed upon parasite egress; this death is necrotic, rather than apoptotic, in nature.

* Corresponding author. Mailing address: The Johns Hopkins Hospital, 406 Pathology Building, 600 N. Wolfe St., Baltimore, MD 21287. Phone: (410) 955-1180. Fax: (410) 614-9556. E-mail: dclark{at}jhmi.edu.

Editor: T. R. Kozel

{dagger} Present address: Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520-8022.

Infection and Immunity, September 2003, p. 5422-5426, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5422-5426.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Liu, J., Enomoto, S., Lancto, C. A., Abrahamsen, M. S., Rutherford, M. S. (2008). Inhibition of Apoptosis in Cryptosporidium parvum-Infected Intestinal Epithelial Cells Is Dependent on Survivin. Infect. Immun. 76: 3784-3792 [Abstract] [Full Text]  
  • Lavine, M. D., Arrizabalaga, G. (2008). Exit from Host Cells by the Pathogenic Parasite Toxoplasma gondii Does Not Require Motility. Eukaryot Cell 7: 131-140 [Abstract] [Full Text]  


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