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Infection and Immunity, September 2003, p. 5432-5435, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5432-5435.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The Small Nucleoid-Binding Proteins H-NS, HU, and Fis Affect hilA Expression in Salmonella enterica Serovar Typhimurium

Lisa M. Schechter,^* Sumita Jain, Samina Akbar, and Catherine A. Lee

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115

Received 1 November 2002/ Returned for modification 3 February 2003/ Accepted 27 May 2003

hilA encodes an activator of Salmonella enterica serovar Typhimurium virulence genes and is transcriptionally modulated by environmental conditions. We show that H-NS represses hilA under low-osmolarity conditions. H-NS, HU, and Fis also appear to affect the derepression of hilA by HilD. Modulation of hilA by counteracting repressing and derepressing mechanisms may allow Salmonella serovar Typhimurium to regulate its virulence genes in response to different situations in vivo.

Editor: V. J. DiRita

Present address: Infectious Disease Division, Massachusetts General Hospital, Cambridge, MA 02139.

Present address: BC Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada.

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