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Infection and Immunity, September 2003, p. 5436-5439, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5436-5439.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Production of FaeG, the Major Subunit of K88 Fimbriae, in Transgenic Tobacco Plants and Its Immunogenicity in Mice

Yahong Huang,1,2 Wanqi Liang,2 Aihu Pan,2 Zhiai Zhou,3 Cheng Huang,1 Jianxiu Chen,1 and Dabing Zhang2*

The Department of Biological Science and Technology, School of Life Science of Nanjing University, Nanjing,1 Shanghai Key Laboratory of Agricultural Genetics and Breeding, Agro-biotech Research Center, and Shanghai Key Laboratory of Agricultural Genetics Breeding,2 The Institute of Animal and Veterinary Sciences, Shanghai Academy of Agricultural Sciences, Shanghai, People's Republic of China3

Received 7 October 2002/ Returned for modification 7 January 2003/ Accepted 27 May 2003

Transgenic tobacco plants stably expressing recombinant FaeG, which is the major subunit and adhesin of K88ad fimbriae, were obtained. Analysis of sera from immunized mice indicates that in mice, the immunogenicity induced by plant-derived FaeG protein is comparable to that generated with traditional approaches.

* Corresponding author. Mailing address: Shanghai Key Laboratory of Agricultural Genetics and Breeding, Agro-Biotech Research Center, Shanghai Academy of Agricultural Sciences, 2901 Beidi Rd., Shanghai 201106, People's Republic of China. Phone and Fax: 0086-21-62208750. E-mail: zdb30{at}hotmail.com.

Editor: V. J. DiRita

Infection and Immunity, September 2003, p. 5436-5439, Vol. 71, No. 9
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.9.5436-5439.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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