This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cabrera, G.
Right arrow Articles by Luty, A. J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cabrera, G.
Right arrow Articles by Luty, A. J. F.

 Previous Article  |  Next Article 

Infection and Immunity, January 2004, p. 284-294, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.284-294.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Immunoglobulin G Isotype Responses to Variant Surface Antigens of Plasmodium falciparum in Healthy Gabonese Adults and Children during and after Successive Malaria Attacks

Gerardo Cabrera,1,{dagger} Clarisse Yone,1,{dagger} Anne E. Tebo,1,{ddagger} Jan van Aaken,1,2,§ Bertrand Lell,1,2 Peter G. Kremsner,1,2 and Adrian J. F. Luty1,2*

Department of Parasitology, Institute for Tropical Medicine, University of Tübingen, D-72074 Tübingen, Germany,1 Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon2

Received 4 August 2003/ Returned for modification 29 September 2003/ Accepted 8 October 2003

We assessed immunoglobulin G (IgG) isotype responses with specificity for the variant surface antigens (VSA) of heterologous Plasmodium falciparum isolates by using flow cytometry and plasma from healthy Gabonese adults and from children during and after two consecutive malaria episodes. The individual isolate-specific antibody profiles differed markedly in terms of their isotype content but were similar for healthy adults and healthy uninfected children. In healthy adults, IgG3 and IgG2 responses were the highest, while in healthy children, IgG3 and IgG4 predominated. A transiently elevated IgG1 response was observed during the second of two successive malaria episodes in children, signaling P. falciparum infection-induced cross-reactive anti-VSA responses. Our findings highlight the prominence of IgG3 in the overall profile of these responses but also indicate a marked age-related increase in the prevalence of anti-VSA antibodies of the classically noncytophilic IgG2 isotype, possibly reflecting the high frequency of the histidine-131 variant of Fc{gamma}RIIA in the Gabonese population.

* Corresponding author. Mailing address: Department of Parasitology, Institute for Tropical Medicine, University of Tübingen, 72074 Tübingen, Germany. Phone: 49 (0)7071 2980228. Fax: 49 (0)7071 29 5189. E-mail: adrian.luty{at}uni-tuebingen.de.

Editor: W. A. Petri, Jr.

{dagger} G.C. and C.Y. contributed equally to this work.

{ddagger} Present address: Dept. of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-2170.

§ Present address: Via Pratocarasso 45, 6500 Bellinzona, Switzerland.

Infection and Immunity, January 2004, p. 284-294, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.284-294.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Tongren, J. E., Corran, P. H., Jarra, W., Langhorne, J., Riley, E. M. (2005). Epitope-Specific Regulation of Immunoglobulin Class Switching in Mice Immunized with Malarial Merozoite Surface Proteins. Infect. Immun. 73: 8119-8129 [Abstract] [Full Text]  
  • Elliott, S. R., Brennan, A. K., Beeson, J. G., Tadesse, E., Molyneux, M. E., Brown, G. V., Rogerson, S. J. (2005). Placental Malaria Induces Variant-Specific Antibodies of the Cytophilic Subtypes Immunoglobulin G1 (IgG1) and IgG3 That Correlate with Adhesion Inhibitory Activity. Infect. Immun. 73: 5903-5907 [Abstract] [Full Text]  
  • Megnekou, R., Staalsoe, T., Taylor, D. W, Leke, R., Hviid, L. (2005). Effects of Pregnancy and Intensity of Plasmodium falciparum Transmission on Immunoglobulin G Subclass Responses to Variant Surface Antigens. Infect. Immun. 73: 4112-4118 [Abstract] [Full Text]  
  • Yone, C. L. R. P., Kremsner, P. G., Luty, A. J. F. (2005). Immunoglobulin G Isotype Responses to Erythrocyte Surface-Expressed Variant Antigens of Plasmodium falciparum Predict Protection from Malaria in African Children. Infect. Immun. 73: 2281-2287 [Abstract] [Full Text]  
  • ABDEL-LATIF, M. S., CABRERA, G., KOHLER, C., KREMSNER, P. G., LUTY, A. J. F. (2004). ANTIBODIES TO RIFIN: A COMPONENT OF NATURALLY ACQUIRED RESPONSES TO PLASMODIUM FALCIPARUM VARIANT SURFACE ANTIGENS ON INFECTED ERYTHROCYTES. Am J Trop Med Hyg 71: 179-186 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»