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Infection and Immunity, January 2004, p. 451-460, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.451-460.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Chlamydia-Infected Cells Continue To Undergo Mitosis and Resist Induction of Apoptosis

Department of Microbiology and Immunology. University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229,¹ Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E OW3, Canada²

Received 23 May 2003/ Returned for modification 23 June 2003/ Accepted 17 September 2003

Both anti- and proapoptotic activities have been reported to occur during chlamydial infection. To reconcile the apparent controversy, we compared host cell apoptotic responses to infection with 17 different chlamydial serovars and strains. None of the serovars caused any biologically significant apoptosis in the infected host cells. Host cells in chlamydia-infected cultures can continue to undergo DNA synthesis and mitosis. Chlamydia-infected cells are resistant to apoptosis induction, although the extent of the antiapoptotic ability varied between serovars. These observations have demonstrated that an anti- but not proapoptotic activity is the prevailing event in chlamydia-infected cultures.

Editor: F. C. Fang

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