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Infection and Immunity, January 2004, p. 570-575, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.570-575.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Stable T-Cell Population Expressing an Effector Cell Surface Phenotype in the Lungs of Mice Chronically Infected with Mycobacterium tuberculosis

Ana Paula Junqueira-Kipnis,* Joanne Turner, Mercedes Gonzalez-Juarrero, Oliver C. Turner, and Ian M. Orme

Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523

Received 25 July 2003/ Returned for modification 2 September 2003/ Accepted 11 September 2003

Analysis of T-cell subsets accumulating in the lungs of C57BL/6 mice chronically infected with Mycobacterium tuberculosis revealed that both CD4 and CD8 T-cell populations expressed a cell surface phenotype consistent with that of effector T cells and that a significant proportion of these cells were in the process of secreting gamma interferon.

* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, CO 80523-1682. Phone: (970) 491-7469. Fax: (970) 491-5125. E-mail: Ana.Kipnis{at}colostate.edu.

Editor: F. C. Fang

Infection and Immunity, January 2004, p. 570-575, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.570-575.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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