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Infection and Immunity, January 2004, p. 589-592, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.589-592.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Inhibition of CD1 Expression in Human Dendritic Cells during Intracellular Infection with Leishmania donovani

Joseph L. Amprey,1,2 Gerald F. Späth,3 and Steven A. Porcelli2*

Weill Medical College of Cornell University,1 Department of Medical and Molecular Parasitology, New York University School of Medicine, New York,3 Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York2

Received 20 June 2003/ Accepted 16 August 2003

Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, 1300 Morris Park Ave., Bronx, NY 10461. Phone: (718) 430-2811. Fax: (718) 430-8711. E-mail: porcelli{at}aecom.yu.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, January 2004, p. 589-592, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.589-592.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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