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Infection and Immunity, January 2004, p. 602-605, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.602-605.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Protection against Anthrax Toxemia by Hexa-D-Arginine In Vitro and In Vivo

Miroslav S. Sarac,1 Juan R. Peinado,1 Stephen H. Leppla,2 and Iris Lindberg1*

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112,1 Microbial Pathogenesis Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208922

Received 22 July 2003/ Returned for modification 21 August 2003/ Accepted 25 September 2003

The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by furin or a furin-like protease. We present here data demonstrating that the small stable furin inhibitor hexa-D-arginine amide delays anthrax toxin-induced toxemia both in cells and in live animals, suggesting that furin inhibition may represent a reasonable avenue for therapeutic intervention in anthrax.


* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112. Phone: (504) 568-4799. Fax: (504) 568-6598. E-mail: ilindb{at}lsuhsc.edu.

Editor: J. T. Barbieri


Infection and Immunity, January 2004, p. 602-605, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.602-605.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.




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