This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sarac, M. S.
Right arrow Articles by Lindberg, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sarac, M. S.
Right arrow Articles by Lindberg, I.

 Previous Article  |  Next Article 

Infection and Immunity, January 2004, p. 602-605, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.602-605.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Protection against Anthrax Toxemia by Hexa-D-Arginine In Vitro and In Vivo

Miroslav S. Sarac,1 Juan R. Peinado,1 Stephen H. Leppla,2 and Iris Lindberg1*

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112,1 Microbial Pathogenesis Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208922

Received 22 July 2003/ Returned for modification 21 August 2003/ Accepted 25 September 2003

The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by furin or a furin-like protease. We present here data demonstrating that the small stable furin inhibitor hexa-D-arginine amide delays anthrax toxin-induced toxemia both in cells and in live animals, suggesting that furin inhibition may represent a reasonable avenue for therapeutic intervention in anthrax.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112. Phone: (504) 568-4799. Fax: (504) 568-6598. E-mail: ilindb{at}lsuhsc.edu.

Editor: J. T. Barbieri

Infection and Immunity, January 2004, p. 602-605, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.602-605.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Komiyama, T., Coppola, J. M., Larsen, M. J., van Dort, M. E., Ross, B. D., Day, R., Rehemtulla, A., Fuller, R. S. (2009). Inhibition of Furin/Proprotein Convertase-catalyzed Surface and Intracellular Processing by Small Molecules. J. Biol. Chem. 284: 15729-15738 [Abstract] [Full Text]  
  • Shiryaev, S. A., Remacle, A. G., Ratnikov, B. I., Nelson, N. A., Savinov, A. Y., Wei, G., Bottini, M., Rega, M. F., Parent, A., Desjardins, R., Fugere, M., Day, R., Sabet, M., Pellecchia, M., Liddington, R. C., Smith, J. W., Mustelin, T., Guiney, D. G., Lebl, M., Strongin, A. Y. (2007). Targeting Host Cell Furin Proprotein Convertases as a Therapeutic Strategy against Bacterial Toxins and Viral Pathogens. J. Biol. Chem. 282: 20847-20853 [Abstract] [Full Text]  
  • Sherer, K., Li, Y., Cui, X., Eichacker, P. Q. (2007). Lethal and Edema Toxins in the Pathogenesis of Bacillus anthracis Septic Shock: Implications for Therapy. Am. J. Respir. Crit. Care Med. 175: 211-221 [Abstract] [Full Text]  
  • Jiao, G.-S., Cregar, L., Wang, J., Millis, S. Z., Tang, C., O'Malley, S., Johnson, A. T., Sareth, S., Larson, J., Thomas, G. (2006). Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine. Proc. Natl. Acad. Sci. USA 103: 19707-19712 [Abstract] [Full Text]  
  • Fang, H., Xu, L., Chen, T. Y., Cyr, J. M., Frucht, D. M. (2006). Anthrax Lethal Toxin Has Direct and Potent Inhibitory Effects on B Cell Proliferation and Immunoglobulin Production. J. Immunol. 176: 6155-6161 [Abstract] [Full Text]  
  • Richards, R. M., Lowy, D. R., Schiller, J. T., Day, P. M. (2006). Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection. Proc. Natl. Acad. Sci. USA 103: 1522-1527 [Abstract] [Full Text]  
  • Komiyama, T., Swanson, J. A., Fuller, R. S. (2005). Protection from Anthrax Toxin-Mediated Killing of Macrophages by the Combined Effects of Furin Inhibitors and Chloroquine. Antimicrob. Agents Chemother. 49: 3875-3882 [Abstract] [Full Text]  
  • Roebroek, A. J. M., Taylor, N. A., Louagie, E., Pauli, I., Smeijers, L., Snellinx, A., Lauwers, A., Van de Ven, W. J. M., Hartmann, D., Creemers, J. W. M. (2004). Limited Redundancy of the Proprotein Convertase Furin in Mouse Liver. J. Biol. Chem. 279: 53442-53450 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»