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Infection and Immunity, January 2004, p. 606-610, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.606-610.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Acquisition of Host Plasmin Activity by the Swine Pathogen Streptococcus suis Serotype 2

Marie-Claude Jobin,1 Julie Brassard,2 Sylvain Quessy,2,3 Marcelo Gottschalk,2,3 and Daniel Grenier1,3*

Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Quebec City,1 Groupe de Recherche sur les Maladies Infectieuses du Porc,2 Canadian Research Network on Bacterial Pathogens of Swine (Natural Sciences and Engineering Research Council of Canada), Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada3

Received 23 July 2003/ Returned for modification 3 September 2003/ Accepted 8 October 2003

In this study, the plasminogen-binding activity of Streptococcus suis serotype 2 was investigated. Bound human plasminogen was activated by purified streptokinase, urokinase, or Streptococcus dysgalactiae subsp. equisimilis culture supernatant. Both human and porcine plasminogen were bound by S. suis. Binding was inhibited by {varepsilon}-aminocaproic acid, and the plasminogen receptor was heat and sodium dodecyl sulfate resistant. One of the receptors was identified as glyceraldehyde-3-phosphate dehydrogenase. S. suis-associated plasmin activity was capable of activating free plasminogen, which in turn could contribute to degradation of fibronectin. This is the first report on the plasminogen-binding activity of S. suis. Further studies may reveal a contribution of this activity to the virulence of S. suis.

* Corresponding author. Mailing address: Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Quebec City, Quebec, Canada G1K 7P4. Phone: (418) 656-7341. Fax: (418) 656-2861. E-mail: Daniel.Grenier{at}greb.ulaval.ca.

Editor: W. A. Petri, Jr.

Infection and Immunity, January 2004, p. 606-610, Vol. 72, No. 1
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.1.606-610.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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