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Infection and Immunity, October 2004, p. 6142-6147, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6142-6147.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Persistence of Burkholderia multivorans within the Pulmonary Macrophage in the Murine Lung

Karen K. Chu,1 Kelly L. MacDonald,2 Donald J. Davidson,3 and David P. Speert3*

Departments of Pathology,1 Microbiology and Immunology,2 Paediatrics, University of British Columbia, Vancouver, British Columbia, Canada3

Received 31 March 2004/ Returned for modification 24 May 2004/ Accepted 30 June 2004

Differences in infection kinetics and host response between Burkholderia multivorans and Burkholderia cenocepacia were demonstrated in a pulmonary infection model in BALB/c mice. B. multivorans persisted in the lung, while B. cenocepacia was cleared. Indirect immunofluorescence and electron microscopy of B. multivorans-infected lungs localized bacteria to macrophages. Clearance of B. cenocepacia was associated with greater interleukin-1ß and neutrophil responses than the responses induced by B. multivorans.

* Corresponding author. Present address: British Columbia Research Institute for Children's and Women's Health, 950 W. 28th Avenue, Rm. 377, Vancouver, British Columbia, Canada V5Z 4H4. Phone: (604) 875-2438. Fax: (604) 875-2226. E-mail: dspeert{at}cw.bc.ca.

Editor: J. T. Barbieri

Infection and Immunity, October 2004, p. 6142-6147, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6142-6147.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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