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Use of Deoxyribose by Intestinal and Extraintestinal Pathogenic Escherichia coli Strains: a Metabolic Adaptation Involved in Competitiveness

Christine Bernier-Fébreau,¹ Laurence du Merle,¹ Evelyne Turlin,² Valérie Labas,³ Juana Ordonez,^1, Anne-Marie Gilles,^2,4, and Chantal Le Bouguénec^1*

Unité de Pathogénie Bactérienne des Muqueuses,¹ Unité de Génétique des Génomes Bactériens,² Laboratoire de Chimie Structurale des Macromolécules, Institut Pasteur,⁴ Laboratoire de Neurobiologie et Diversité Cellulaire, ESPCI, Paris, France³

Received 20 April 2004/ Returned for modification 24 May 2004/ Accepted 3 July 2004

We showed that the deoK operon, which confers the ability to use deoxyribose as a carbon source, is more common among pathogenic than commensal Escherichia coli strains. The expression of the deoK operon increases the competitiveness of clinical isolates, suggesting that this biochemical characteristic plays a role in host infectivity.

Editor: J. T. Barbieri

Present address: Laboratorio Especial de Microbiologia, Instituto Butatan, 05503-900 Sao Paulo, SP, Brazil.

Present address: Unité de Génétique des Génomes Bactériens, Institut Pasteur, Paris, France.

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