IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lee, Y.-R.
Right arrow Articles by Kim, J.-S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, Y.-R.
Right arrow Articles by Kim, J.-S.
Infection and Immunity, October 2004, p. 6157-6159, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6157-6159.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

A Calcium-Calmodulin Antagonist Blocks Experimental Vibrio vulnificus Cytolysin-Induced Lethality in an Experimental Mouse Model

Young-Rae Lee,1 Kwang-Hyun Park,1 Zhao-Zhen Lin,1 Young-Jong Kho,1 Jin-Woo Park,1 Hye-Won Rho,1 Bon-Sun Koo,1 Hyung-Rho Kim,1 Eun-Kyung Song,2 Hong-Nu Yu,2 Myung-Kwan Han,2 Seung-Ok Lee,3 Eun-Chung Jhee,4 and Jong-Suk Kim1*

Departments of Biochemistry,1 Microbiology and Immunology,2 Internal Medicine, Chonbuk National University Medical School,3 Department of Biochemistry, Chonbuk National University Dental School, Chonju, Republic of Korea4

Received 22 April 2004/ Returned for modification 9 June 2004/ Accepted 28 June 2004

We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.

* Corresponding author. Mailing address: Department of Biochemistry, Chonbuk National University Medical School, Chonju 560-182, Republic of Korea. Phone: 82-63-270-3085. Fax: 82-63-274-9833. E-mail: jsukim{at}moak.chonbuk.ac.kr.

Editor: J. T. Barbieri

Infection and Immunity, October 2004, p. 6157-6159, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6157-6159.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 2004 by the American Society for Microbiology. All rights reserved.