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Infection and Immunity, October 2004, p. 6157-6159, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6157-6159.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

A Calcium-Calmodulin Antagonist Blocks Experimental Vibrio vulnificus Cytolysin-Induced Lethality in an Experimental Mouse Model

Young-Rae Lee,1 Kwang-Hyun Park,1 Zhao-Zhen Lin,1 Young-Jong Kho,1 Jin-Woo Park,1 Hye-Won Rho,1 Bon-Sun Koo,1 Hyung-Rho Kim,1 Eun-Kyung Song,2 Hong-Nu Yu,2 Myung-Kwan Han,2 Seung-Ok Lee,3 Eun-Chung Jhee,4 and Jong-Suk Kim1*

Departments of Biochemistry,1 Microbiology and Immunology,2 Internal Medicine, Chonbuk National University Medical School,3 Department of Biochemistry, Chonbuk National University Dental School, Chonju, Republic of Korea4

Received 22 April 2004/ Returned for modification 9 June 2004/ Accepted 28 June 2004

We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.

* Corresponding author. Mailing address: Department of Biochemistry, Chonbuk National University Medical School, Chonju 560-182, Republic of Korea. Phone: 82-63-270-3085. Fax: 82-63-274-9833. E-mail: jsukim{at}moak.chonbuk.ac.kr.

Editor: J. T. Barbieri

Infection and Immunity, October 2004, p. 6157-6159, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6157-6159.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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