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Infection and Immunity, October 2004, p. 6164-6167, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6164-6167.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Extracellular Adherence Protein from Staphylococcus aureus Inhibits Neutrophil Binding to Endothelial Cells

Axana Haggar,1 Cecilia Ehrnfelt,2 Jan Holgersson,2 and Jan-Ingmar Flock1*

Divisions of Clinical Bacteriology,1 Immunology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden2

Received 25 March 2004/ Returned for modification 23 April 2004/ Accepted 25 June 2004

Extracellular adherence protein (Eap) from Staphylococcus aureus inhibits the adherence of neutrophils to nonstimulated and tumor necrosis factor alpha-stimulated endothelial cells in both static adhesion assays and flow adhesion assays. Consequently, Eap also impaired their transendothelial migration. During an S. aureus infection, Eap may thus serve to reduce inflammation by inhibiting neutrophil adhesion and extravasation.

* Corresponding author. Mailing address: Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Bacteriology, Huddinge University Hospital, F82, S-141 86 Stockholm, Sweden. Phone: 46 8 58581169. Fax: 46 8 7113918. E-mail: jan-ingmar.flock{at}labmed.ki.se.

Editor: J. D. Clements

Infection and Immunity, October 2004, p. 6164-6167, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6164-6167.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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