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Infection and Immunity, October 2004, p. 6172-6175, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6172-6175.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Oral Immunization with a Combination of Plasmodium yoelii Merozoite Surface Proteins 1 and 4/5 Enhances Protection against Lethal Malaria Challenge

Lina Wang,1 Matthew W. Goschnick,1 and Ross L. Coppel1,2*

Department of Microbiology,a Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia,b

Received 2 May 2004/ Returned for modification 4 June 2004/ Accepted 24 June 2004

Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody responses and protected mice against lethal malaria infection. A combination of these two proteins administered orally conferred improved protection compared to that conferred by either protein administered alone.

* Corresponding author. Mailing address: Department of Microbiology, P.O. Box 53, Monash University, Clayton, Victoria, Australia. Phone: 61 3 9905 4822. Fax: 61 3 9905 4811. E-mail: ross.coppel{at}med.monash.edu.au.

Editor: W. A. Petri, Jr.

Infection and Immunity, October 2004, p. 6172-6175, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6172-6175.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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