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Infection and Immunity, October 2004, p. 6181-6184, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6181-6184.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

A Peptide Domain of Bovine Milk Lactoferrin Inhibits the Interaction between Streptococcal Surface Protein Antigen and a Salivary Agglutinin Peptide Domain

Takahiko Oho,1* Floris J. Bikker,2 Arie V. Nieuw Amerongen,2 and Jasper Groenink2

Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan,1 Department of Dental Basic Sciences, Section of Oral Biochemistry, Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands2

Received 24 May 2004/ Returned for modification 21 June 2004/ Accepted 2 July 2004

The peptide domain of salivary agglutinin responsible for its interaction with cell surface protein antigen (PAc) of Streptococcus mutans or bovine lactoferrin was found in the same peptide, scavenger receptor cysteine-rich domain peptide 2 (SRCRP2). Inhibition studies suggest that PAc and lactoferrin, of which residues 480 to 492 seem important, competitively bind to the SRCRP2 domain of salivary agglutinin.

* Corresponding author. Present address: Department of Preventive Dentistry, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan. Phone: 81-99-275-6180. Fax: 81-99-275-6188. E-mail: oho{at}denta.hal.kagoshima-u.ac.jp.

Editor: J. B. Bliska

Infection and Immunity, October 2004, p. 6181-6184, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6181-6184.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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