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Infection and Immunity, October 2004, p. 6185-6189, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6185-6189.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Fine Specificity, but Not the Invasion Inhibitory Activity, of 19-Kilodalton Merozoite Surface Protein 1-Specific Antibodies Is Associated with Resistance to Malarial Parasitemia in a Cross-Sectional Survey in The Gambia{dagger}

Patrick H. Corran,1,2* Rebecca A. O'Donnell,3,{ddagger} Jim Todd,1 Chairat Uthaipibull,4,§ Anthony A. Holder,4 Brendan S. Crabb,3 and Eleanor M. Riley1

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine,1 Division of Parasitology, National Institute for Medical Research, London,4 Immunobiology Division, National Institute for Biological Standards and Control, South Mimms, United Kingdom,2 The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia3

Received 30 March 2004/ Returned for modification 22 May 2004/ Accepted 2 July 2004

In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-119)-specific erythrocyte invasion inhibitory activity of antibodies to MSP-119 but find no significant association between any of these parameters and prevalence or density of malarial parasitemia, except that, after correcting for total anti-MSP-119 antibody levels, individuals with anti-MSP-119 antibodies that compete with an invasion inhibitory monoclonal antibody (12.10) were significantly less likely to have malaria infections with densities of ≥1,000 parasites/µl than were individuals without such antibodies. This association persisted after correction for age and ethnic origin.

* Corresponding author. Mailing address: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. Phone: (44) 207 927 2706. Fax: (44) 207 927 2807. E-mail: patrick.corran{at}lshtm.ac.uk.

{dagger} This work is dedicated to the memory of Steve Bennett, who died in March 2003 at the age of 52 years.

Editor: W. A. Petri, Jr.

{ddagger} Present address: Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

§ Present address: Protein-Ligand Engineering and Molecular Biology Laboratory, National Center for Genetic Engineering and Biotechnology, Klong Luang, Pathumthani 12120, Thailand.

Infection and Immunity, October 2004, p. 6185-6189, Vol. 72, No. 10
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.10.6185-6189.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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