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Infection and Immunity, November 2004, p. 6676-6679, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6676-6679.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Mucosal Administration of Flagellin Induces Innate Immunity in the Mouse Lung

Anna N. Honko and Steven B. Mizel*

Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

Received 2 June 2004/ Returned for modification 13 July 2004/ Accepted 2 August 2004

Nonsurgical intratracheal instillation of 1 µg of purified, recombinant flagellin in several strains of mice stimulated a transient innate immune response in the lung characterized by the infiltration of neutrophils and the rapid production of tumor necrosis factor alpha, interleukin 6, granulocyte colony-stimulating factor, and the chemokines keratinocyte-derived chemokine, MIP1{alpha}, and MIP-2.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157. Phone: (336) 716-2216. Fax: (336) 716-9928. E-mail: smizel{at}wfubmc.edu.

Editor: F. C. Fang

Infection and Immunity, November 2004, p. 6676-6679, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6676-6679.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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