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Infection and Immunity, November 2004, p. 6685-6688, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6685-6688.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Human Factor in Staphylococcus aureus Nasal Carriage

Jan Nouwen,* Hélène Boelens, Alex van Belkum,* and Henri Verbrugh

Department of Medical Microbiology & Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands

Received 6 April 2004/ Returned for modification 4 May 2004/ Accepted 9 June 2004

Persistent nasal carriers and noncarriers of Staphylococcus aureus were inoculated with a mixture of different S. aureus strains. The majority of noncarriers and nearly all persistent carriers returned to their original carrier state after artificial inoculation. Furthermore, the majority of persistent carriers tested positive again for their original resident strain. Using a human nasal inoculation model, we here demonstrate that the human factor is an important determinant of S. aureus nasal carriage.

* Corresponding author. Mailing address: Erasmus MC, Department of Medical Microbiology & Infectious Diseases, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. Phone: 31 10 463 3511. Fax: 31 10 463 3875. E-mail for J. Nouwen: j.l.nouwen{at}erasmusmc.nl. E-mail for A. van Belkum: a.vanbelkum{at}erasmusmc.nl.

Editor: J. N. Weiser

Infection and Immunity, November 2004, p. 6685-6688, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6685-6688.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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