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Cleavage of the N-Linked Oligosaccharide from the Surfaces of Chlamydia Species Affects Attachment and Infectivity of the Organisms in Human Epithelial and Endothelial Cells

Department of Pathobiology, University of Washington, Seattle, Washington

Received 14 June 2004/ Returned for modification 19 July 2004/ Accepted 1 August 2004

Previous studies demonstrated that the high-mannose oligosaccharide N linked to the Chlamydia major outer membrane protein inhibited the attachment and infectivity of the organism. The present study showed that cleavage of the glycan with N-glycanase decreased the attachment and infectivity of chlamydial organisms in human epithelial and endothelial cells.

Editor: J. T. Barbieri

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