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Infection and Immunity, November 2004, p. 6729-6732, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6729-6732.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Interleukin-15-Deficient Mice Develop Protective Immunity to Toxoplasma gondii

Linda A. Lieberman, Eric N. Villegas,{dagger} and Christopher A. Hunter*

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Received 8 June 2004/ Returned for modification 13 July 2004/ Accepted 29 July 2004

Previous studies have suggested an important role for interleukin-15 (IL-15) in resistance to and memory for Toxoplasma gondii infection. The studies presented here reveal that IL-15 is not required for infection-induced expansion of NK or CD8+ T cells. Furthermore, IL-15–/– mice develop long-term protective immunity to this pathogen.

* Corresponding author. Mailing address: Department of Pathobiology, School of Veterinary Medicine, Rosenthal Bldg., Room 226, 3800 Spruce St., University of Pennsylvania, Philadelphia, PA 19104. Phone: (215) 573-7772. Fax: (215) 573-7023. E-mail: chunter{at}vet.upenn.edu.

Editor: W. A. Petri, Jr.

{dagger} Present address: Molecular and Cellular Biology Department, Immunology Division, University of California at Berkeley, Berkeley, CA 94720-3200.

Infection and Immunity, November 2004, p. 6729-6732, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6729-6732.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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