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Infection and Immunity, November 2004, p. 6733-6737, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6733-6737.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro and In Vivo Evaluation of Staphylococcal Superantigen Peptide Antagonists

Govindarajan Rajagopalan, Moon M. Sen, and Chella S. David*

Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota

Received 10 February 2004/ Returned for modification 30 March 2004/ Accepted 1 June 2004

Superantigen peptide antagonists failed to block T-cell activation and cytokine production as well as toxic shock induced by staphylococcal enterotoxin B (SEB) in HLA class II transgenic mice. They also failed to inhibit the binding of SEB to HLA class II molecules as well as activation of human T lymphocytes in vitro.

* Corresponding author. Mailing address: Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First St., SW, Rochester, MN 55905. Phone: (507) 284-8180. Fax: (507) 266-0981. E-mail: davic4{at}mayo.edu.

Editor: A. D. O'Brien

Infection and Immunity, November 2004, p. 6733-6737, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6733-6737.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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