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Infection and Immunity, November 2004, p. 6738-6742, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6738-6742.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Lack of Stage-Specific Proteins in Coccoid Helicobacter pylori Cells

Dirk Bumann,1 Hajar Habibi,1 Biao Kan,2 Monika Schmid,2 Christian Goosmann,3 Volker Brinkmann,3 Thomas F. Meyer,1* and Peter R. Jungblut2

Department of Molecular Biology,1 Central Core Facility for Protein Analysis,2 Central Core Facility for Microscopy, Max-Planck-Institute for Infection Biology, Berlin, Germany3

Received 28 May 2004/ Returned for modification 5 July 2004/ Accepted 9 August 2004

Helicobacter pylori exists in two distinct forms, rod shaped or coccoid, in stomachs of infected patients. Based on in vitro proteome comparisons, there are no detectable coccoid-specific proteins, which argues against the specific adaptation of coccoid Helicobacter to distinct biological functions, such as enhanced persistence or transmission to other hosts.


* Corresponding author. Mailing address: Abteilung Molekulare Biologie, Max-Planck-Institut für Infektionsbiologie, Schumannstraße 21/22, D-10117 Berlin, Germany. Phone: 49 30 28460 400. Fax: 49 30 28460 401. E-mail: meyer{at}mpiib-berlin.mpg.de.

Editor: J. T. Barbieri


Infection and Immunity, November 2004, p. 6738-6742, Vol. 72, No. 11
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.11.6738-6742.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.




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