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Infection and Immunity, December 2004, p. 7311-7314, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7311-7314.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Expression of a ß-Defensin mRNA, Lingual Antimicrobial Peptide, in Bovine Mammary Epithelial Tissue Is Induced by Mastitis

Kara Swanson,1,2* Stas Gorodetsky,3 Laura Good,1 Stephen Davis,1 David Musgrave,2 Kerst Stelwagen,1 Vicki Farr,1 and Adrian Molenaar1

AgResearch, Ruakura Research Centre,1 Department of Biological Sciences, University of Waikato, Hamilton, New Zealand,2 Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia3

Received 10 April 2004/ Returned for modification 21 June 2004/ Accepted 16 August 2004

The expression of a ß-defensin, the lingual antimicrobial peptide (LAP), in response to mastitis was investigated by real-time PCR of RNA from mastitic and control udder quarters. There was a positive relationship between somatic cell count in milk and LAP expression. In situ hybridization showed that LAP mRNA was expressed in epithelial cells of mastitic tissue. These results suggest that LAP plays a role in the innate immune response to mastitis.

* Corresponding author. Mailing address: Dairy Biotechnology, AgResearch, Hamilton, New Zealand. Phone: 64 3 467 5758. Fax: 64 3 479 8540. E-mail: kara.swanson{at}agresearch.co.nz.

Editor: A. D. O'Brien

Infection and Immunity, December 2004, p. 7311-7314, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7311-7314.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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