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Infection and Immunity, December 2004, p. 7318-7321, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7318-7321.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Oral Vaccination with Recombinant Yersinia enterocolitica Expressing Hybrid Type III Proteins Protects Gerbils from Amebic Liver Abscess

Hannelore Lotter,1 Holger Rüssmann,2 Jürgen Heesemann,2 and Egbert Tannich1*

Department of Molecular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg,1 Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Munich, Germany2

Received 3 May 2004/ Returned for modification 7 June 2004/ Accepted 24 August 2004

Protection against invasive amebiasis was achieved in the gerbil model for amebic liver abscess by oral immunization with live attenuated Yersinia enterocolitica expressing the Entamoeba histolytica galactose-inhibitable lectin that has been fused to the Yersinia outer protein E (YopE). Protection was dependent on the presence of the YopE translocation domain but was independent from the antibody response to the ameba lectin.

* Corresponding author. Mailing address: Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Str. 74, 20359 Hamburg, Germany. Phone: 49-40-42 818 477. Fax: 49-40-42 818 512. E-mail: tannich{at}bni-hamburg.de.

Editor: J. B. Bliska

Infection and Immunity, December 2004, p. 7318-7321, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7318-7321.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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Copyright © 2004 by the American Society for Microbiology. All rights reserved.