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Infection and Immunity, December 2004, p. 7322-7325, Vol. 72, No. 12
0019-9567/04/$08.00+0 DOI: 10.1128/IAI.72.12.7322-7325.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
Departments of Microbiology,1 Genetics, University of Alabama at Birmingham, Birmingham, Alabama2
Received 30 June 2004/ Returned for modification 24 August 2004/ Accepted 30 August 2004
Previous studies demonstrated that Mycoplasma arthritidis strain 158 acquired a high degree of virulence upon lysogenization with bacteriophage MAV1. In the present study, the association between MAV1 and virulence was reexamined by creating new lysogens of 158 and of a relatively avirulent mutant, strain 158-1. In the absence of lysogenization, 158 was more virulent than expected. The virulence of 158 and 158-1 did not increase upon lysogenization. A major antigenic difference between 158 and 158-1 was identified that is unrelated to MAV1 and could account for the difference in virulence.
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