This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Onyewu, C.
Right arrow Articles by Heitman, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Onyewu, C.
Right arrow Articles by Heitman, J.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH

 Previous Article  |  Next Article 

Infection and Immunity, December 2004, p. 7330-7333, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7330-7333.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicans

Chiatogu Onyewu,1 Floyd L. Wormley Jr.,2 John R. Perfect,2 and Joseph Heitman1,2,3,4*

Departments of Molecular Genetics and Microbiology,3 Medicine,2 Pharmacology and Cancer Biology,1 Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina4

Received 2 August 2004/ Returned for modification 23 August 2004/ Accepted 2 September 2004

In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae. However, the in vitro phenotypes of C. albicans crz1/crz1 and calcineurin mutants differ and Crz1 is not required for virulence.

* Corresponding author. Mailing address: Department of Molecular Genetics and Microbiology, 322 Carl Building, Box 3546, Research Dr., Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-2824. Fax: (919) 684-5458. E-mail: heitm001{at}duke.edu.

Editor: T. R. Kozel

Infection and Immunity, December 2004, p. 7330-7333, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7330-7333.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., Tanabe, K., Niimi, M., Goffeau, A., Monk, B. C. (2009). Efflux-Mediated Antifungal Drug Resistance. Clin. Microbiol. Rev. 22: 291-321 [Abstract] [Full Text]  
  • Cramer, R. A. Jr., Perfect, B. Z., Pinchai, N., Park, S., Perlin, D. S., Asfaw, Y. G., Heitman, J., Perfect, J. R., Steinbach, W. J. (2008). Calcineurin Target CrzA Regulates Conidial Germination, Hyphal Growth, and Pathogenesis of Aspergillus fumigatus. Eukaryot Cell 7: 1085-1097 [Abstract] [Full Text]  
  • Cowen, L. E., Steinbach, W. J. (2008). Stress, Drugs, and Evolution: the Role of Cellular Signaling in Fungal Drug Resistance. Eukaryot Cell 7: 747-764 [Full Text]  
  • Schumacher, J., de Larrinoa, I. F., Tudzynski, B. (2008). Calcineurin-Responsive Zinc Finger Transcription Factor CRZ1 of Botrytis cinerea Is Required for Growth, Development, and Full Virulence on Bean Plants. Eukaryot Cell 7: 584-601 [Abstract] [Full Text]  
  • Uppuluri, P., Nett, J., Heitman, J., Andes, D. (2008). Synergistic Effect of Calcineurin Inhibitors and Fluconazole against Candida albicans Biofilms. Antimicrob. Agents Chemother. 52: 1127-1132 [Abstract] [Full Text]  
  • Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Tanabe, K., Niimi, M., Monk, B. C. (2007). Candida albicans drug resistance another way to cope with stress. Microbiology 153: 3211-3217 [Abstract] [Full Text]  
  • Panadero, J., Hernandez-Lopez, M. J., Prieto, J. A., Randez-Gil, F. (2007). Overexpression of the Calcineurin Target CRZ1 Provides Freeze Tolerance and Enhances the Fermentative Capacity of Baker's Yeast. Appl. Environ. Microbiol. 73: 4824-4831 [Abstract] [Full Text]  
  • Cowen, L. E., Carpenter, A. E., Matangkasombut, O., Fink, G. R., Lindquist, S. (2006). Genetic Architecture of Hsp90-Dependent Drug Resistance. Eukaryot Cell 5: 2184-2188 [Abstract] [Full Text]  
  • Onyewu, C., Afshari, N. A., Heitman, J. (2006). Calcineurin Promotes Infection of the Cornea by Candida albicans and Can Be Targeted To Enhance Fluconazole Therapy. Antimicrob. Agents Chemother. 50: 3963-3965 [Abstract] [Full Text]  
  • Hernandez-Lopez, M. J., Panadero, J., Prieto, J. A., Randez-Gil, F. (2006). Regulation of Salt Tolerance by Torulaspora delbrueckii Calcineurin Target Crz1p. Eukaryot Cell 5: 469-479 [Abstract] [Full Text]  
  • Blankenship, J. R., Heitman, J. (2005). Calcineurin Is Required for Candida albicans To Survive Calcium Stress in Serum. Infect. Immun. 73: 5767-5774 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»