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Infection and Immunity, December 2004, p. 7330-7333, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7330-7333.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicans

Chiatogu Onyewu,1 Floyd L. Wormley Jr.,2 John R. Perfect,2 and Joseph Heitman1,2,3,4*

Departments of Molecular Genetics and Microbiology,3 Medicine,2 Pharmacology and Cancer Biology,1 Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina4

Received 2 August 2004/ Returned for modification 23 August 2004/ Accepted 2 September 2004

In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae. However, the in vitro phenotypes of C. albicans crz1/crz1 and calcineurin mutants differ and Crz1 is not required for virulence.

* Corresponding author. Mailing address: Department of Molecular Genetics and Microbiology, 322 Carl Building, Box 3546, Research Dr., Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-2824. Fax: (919) 684-5458. E-mail: heitm001{at}duke.edu.

Editor: T. R. Kozel

Infection and Immunity, December 2004, p. 7330-7333, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7330-7333.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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