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Infection and Immunity, December 2004, p. 7346-7351, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7346-7351.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Acellular Pertussis Vaccines and Complement Killing of Bordetella pertussis

Alison A. Weiss,1* Angela K. Patton,1 Scott H. Millen,1 Swei-Ju Chang,2 Joel I. Ward,2 and David I. Bernstein3

Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio,1 UCLA Center for Vaccine Research, Harbor-UCLA Medical Center, Torrance, California,2 Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio3

Received 9 July 2004/ Returned for modification 24 August 2004/ Accepted 2 September 2004

Antibody-dependent complement killing of Bordetella pertussis after immunization with a three-component acellular pertussis vaccine was characterized. Postimmunization activity was unchanged for about half of the adult vaccine recipients. The responses of the other individuals were complex, with evidence of both beneficial and antagonistic responses occurring, sometimes in the same individual.

* Corresponding author. Mailing address: Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267-0524. Phone: (513) 558-2820. Fax: (513) 558-8474. E-mail: Alison.Weiss{at}uc.edu.

Editor: J. T. Barbieri

Infection and Immunity, December 2004, p. 7346-7351, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7346-7351.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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Copyright © 2004 by the American Society for Microbiology. All rights reserved.