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Infection and Immunity, December 2004, p. 7367-7373, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7367-7373.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Lipid Raft-Mediated Entry Is Not Required for Chlamydia trachomatis Infection of Cultured Epithelial Cells

B. R. Gabel,1 C. Elwell,1 S. C. D. van Ijzendoorn,2,{dagger} and J. N. Engel1,3,4*

Departments of Medicine,1 Microbiology and Immunology,3 Anatomy,4 The Cardiovascular Research Institute, University of California—San Francisco, San Francisco, California2

Received 12 March 2004/ Returned for modification 17 May 2004/ Accepted 24 August 2004

Using pharmacologic and biochemical criteria, we evaluated whether uptake of four different Chlamydia trachomatis serovars, D, E, K, and L2, was dependent upon lipid rafts. Our data suggest that lipid raft-mediated entry is not required for C. trachomatis infection of cultured epithelial cells.

* Corresponding author. Mailing address: Division of Infectious Disease, Box 0654, University of California, San Francisco, CA 94143-0654. Phone: (415) 476-7355. Fax: (415) 476-9364. E-mail: Jengel{at}medicine.ucsf.edu.

Editor: F. C. Fang

{dagger} Present address: Department of Membrane Cell Biology, University of Groningen, Groningen, The Netherlands.

Infection and Immunity, December 2004, p. 7367-7373, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7367-7373.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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