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Infection and Immunity, December 2004, p. 7374-7378, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7374-7378.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Listeria monocytogenes {sigma}B Contributes to Invasion of Human Intestinal Epithelial Cells

Heesun Kim,1 Kathryn J. Boor,1 and Hélène Marquis2*

Department of Food Science,1 Department of Microbiology and Immunology, Cornell University, Ithaca, New York2

Received 20 April 2004/ Returned for modification 18 June 2004/ Accepted 24 August 2004

The role of {sigma}B in Listeria monocytogenes infection of human intestinal epithelial cells was investigated. Invasion defects associated with loss of {sigma}B paralleled those of a {Delta}inlA strain independently of the {sigma}B-dependent P2prfA promoter. Concomitantly, amounts of inlA transcript and InlA protein were significantly decreased in the {Delta}sigB strain.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, VMC 5-169, Cornell University, Ithaca, NY 14853. Phone: (607) 253-3273. Fax: (607) 253-3384. E-mail: hm72{at}cornell.edu.

Editor: V. J. DiRita

Infection and Immunity, December 2004, p. 7374-7378, Vol. 72, No. 12
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.12.7374-7378.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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