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Infection and Immunity, February 2004, p. 1147-1149, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1147-1149.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Rapid Accumulation of Eosinophils in Lung Lesions in Guinea Pigs Infected with Mycobacterium tuberculosis

Todd M. Lasco,1* Oliver C. Turner,1 Lynne Cassone,2 Isamu Sugawara,3 Hiroyuki Yamada,3 David N. McMurray,4 and Ian M. Orme1

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523,1 College of Veterinary Medicine, Texas A&M University,2 Department of Medical Microbiology and Immunology, The Texas A&M University System-Health Science Center, College Station, Texas 77843,4 The Research Institute of Tuberculosis, Matsuyama, Kiyose, Tokyo, Japan3

Received 14 July 2003/ Returned for modification 9 September 2003/ Accepted 6 November 2003

Guinea pig eosinophils were positively identified in bronchoalveolar lavage populations and in the lung granulomas of Mycobacterium tuberculosis-infected guinea pigs. It is possible that the rapid influx of these cells, and their subsequent degranulation during acute pulmonary tuberculosis, may play a key role in the susceptibility of this animal model.

* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Pathology, Colorado State University, 320B Microbiology Building, 682 Campus Delivery, Fort Collins, CO 80523-1682. Phone: (970) 491-7469. Fax: (970) 491-5125. E-mail: Todd.Lasco{at}colostate.edu.

Editor: S. H. E. Kaufmann

Infection and Immunity, February 2004, p. 1147-1149, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1147-1149.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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