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Infection and Immunity, February 2004, p. 1166-1168, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1166-1168.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Periodontitis Vaccine Decreases Local Prostaglandin E2 Levels in a Primate Model

Frank A. Roberts,1* Laura S. Houston,1 Sheila A. Lukehart,2 Lloyd A. Mancl,3 G. Rutger Persson,1 and Roy C. Page1

Departments of Periodontics,1 Medicine,2 Dental Public Health Sciences, University of Washington, Seattle, Washington 981953

Received 28 July 2003/ Returned for modification 15 September 2003/ Accepted 10 November 2003

Interleukin-1ß, tumor necrosis factor alpha, prostaglandin E2 (PGE2), and Porphyromonas gingivalis-specific immunoglobulin G levels in gingival crevicular fluid were measured in primates immunized with a P. gingivalis vaccine followed by ligature-induced periodontitis. Only PGE2 levels were dramatically suppressed (P < 0.0001) in immunized animals versus controls. A significant correlation (P < 0.027) was also found between PGE2 levels and decreased bone loss scores. This study presents the first evidence of a potential mechanism involved in periodontitis vaccine-induced suppression of bone loss in a nonhuman primate model and offers insight into the role of PGE2 in periodontal destruction.

* Corresponding author. Mailing address: University of Washington, Department of Periodontics, Box 357444, Seattle, WA 98195-7444. Phone: (206) 685-9046. Fax: (206) 616-7478. E-mail: froberts{at}u.washington.edu.

Editor: D. L. Burns

Infection and Immunity, February 2004, p. 1166-1168, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1166-1168.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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Copyright © 2004 by the American Society for Microbiology. All rights reserved.