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Activated THP-1 Cells: an Attractive Model for the Assessment of Intracellular Growth Rates of Mycobacterium tuberculosis Isolates

Central Arkansas Veterans Healthcare System, Departments of Pathology, Microbiology-Immunology, and Anatomy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205

Received 30 May 2003/ Returned for modification 13 August 2003/ Accepted 6 November 2003

Capacity of certain Mycobacterium tuberculosis isolates to grow more rapidly in human macrophages may be indicative of increased virulence. Significant differences were observed in intracellular growth of two isolates from sites of tuberculosis transmission, with an outbreak-associated strain growing faster than a strain causing disease in only one person. Activated THP-1 cells are a suitable alternative to peripheral blood monocyte models.

Editor: S. H. E. Kaufmann

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