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Infection and Immunity, February 2004, p. 1181-1183, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1181-1183.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Needle-Free Skin Patch Vaccination Method for Anthrax

Gary R. Matyas,1* Arthur M. Friedlander,2 Gregory M. Glenn,3 Stephen Little,2 Jianmei Yu,3 and Carl R. Alving1

Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910,1 U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702,2 Iomai Corporation, Gaithersburg, Maryland 208783

Received 15 August 2003/ Returned for modification 7 November 2003/ Accepted 14 November 2003

Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal anthrax challenge.

* Corresponding author. Mailing address: Department of Membrane Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Ave., Silver Spring, MD 20910-7500. Phone: (301) 319-9477. Fax: (301) 319-9035. E-mail: gary.matyas{at}na.amedd.army.mil.

Editor: A. D. O'Brien

Infection and Immunity, February 2004, p. 1181-1183, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1181-1183.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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  • Barth, H., Aktories, K., Popoff, M. R., Stiles, B. G. (2004). Binary Bacterial Toxins: Biochemistry, Biology, and Applications of Common Clostridium and Bacillus Proteins. Microbiol. Mol. Biol. Rev. 68: 373-402 [Abstract] [Full Text]  


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