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Infection and Immunity, February 2004, p. 1184-1187, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1184-1187.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Intranasal Immunization of Mice with Group B Streptococcal Protein Rib and Cholera Toxin B Subunit Confers Protection against Lethal Infection

Charlotte Larsson,1* Jan Holmgren,2 Gunnar Lindahl,1 and Charlotta Bergquist2

Department of Medical Microbiology, Dermatology and Infection, Lund University, Lund,1 Department of Medical Microbiology and Immunology, Göteborg University, Göteborg, Sweden2

Received 10 September 2003/ Returned for modification 9 October 2003/ Accepted 14 November 2003

Intranasal immunization of mice with Rib, a cell surface protein of group B streptococcus (GBS), conjugated to or simply coadministered with the recombinant cholera toxin B subunit, induces systemic immunoglobulin G (IgG) and local IgA antibody responses and confers protection against lethal GBS infection. These findings have implications for the development of a human GBS vaccine.

* Corresponding author. Mailing address: Department of Medical Microbiology, Dermatology and Infection, Lund University, Sölvegatan 23, S-22362 Lund, Sweden. Phone: 46 46 173243. Fax: 46 46 135936. E-mail: charlotte.larsson{at}mmb.lu.se.

Editor: D. L. Burns

Infection and Immunity, February 2004, p. 1184-1187, Vol. 72, No. 2
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.2.1184-1187.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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