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The Siderophore Receptor IroN, but Not the High-Pathogenicity Island or the Hemin Receptor ChuA, Contributes to the Bacteremic Step of Escherichia coli Neonatal Meningitis

Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris 7, Service de Microbiologie, Hôpital Robert Debré (AP-HP), 75019 Paris,¹ INSERM U570, Faculté de Médecine Necker-Enfants Malades, 75730 Paris cedex 15, France,³ Max von Pettenkofer-Institut, 80336 Munich, Germany²

Received 25 July 2003/ Returned for modification 5 September 2003/ Accepted 12 November 2003

Using a neonatal rat meningitis model, we examined the involvement of three iron uptake systems, namely, the high-pathogenicity island, the hemin receptor ChuA, and the siderophore receptor IroN, in the pathogenesis of Escherichia coli neonatal meningitis. Only IroN appeared to play a major role during the bacteremic step of the disease.

Editor: J. N. Weiser

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