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Infection and Immunity, March 2004, p. 1795-1798, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1795-1798.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Inhibitory Effect of Antiserum to Surface Antigen P50 of Babesia gibsoni on Growth of Parasites in Severe Combined Immunodeficiency Mice Given Canine Red Blood Cells

Shinya Fukumoto,1 Xuenan Xuan,1 Noriyuki Takabatake,1 Ikuo Igarashi,1 Chihiro Sugimoto,1 Kozo Fujisaki,1 Hideyuki Nagasawa,1 Takeshi Mikami,2 and Hiroshi Suzuki1*

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555,1 Laboratory of Veterinary Public Health, College of Bioresource Science, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan2

Received 8 July 2003/ Returned for modification 3 September 2003/ Accepted 1 December 2003

The inhibitory effect of an antiserum to surface protein P50 of Babesia gibsoni on the growth of the parasite was determined with severe combined immunodeficiency mice given canine red blood cells. The antiserum to the recombinant P50 protein significantly inhibited the parasite growth, indicating that P50 might be a useful vaccine candidate.

* Corresponding author. Mailing address: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Phone: 81-155-49-5640. Fax: 81-155-49-5643. E-mail: hisuzuki{at}obihiro.ac.jp.

Editor: W. A. Petri, Jr.

Infection and Immunity, March 2004, p. 1795-1798, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1795-1798.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Fukumoto, S., Tamaki, Y., Shirafuji, H., Harakawa, S., Suzuki, H., Xuan, X. (2005). Immunization with Recombinant Surface Antigen P50 of Babesia gibsoni Expressed in Insect Cells Induced Parasite Growth Inhibition in Dogs. CVI 12: 557-559 [Abstract] [Full Text]  


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