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Infection and Immunity, March 2004, p. 1799-1803, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1799-1803.2004

Identification of srv, a PrfA-Like Regulator of Group A Streptococcus That Influences Virulence

Sean D. Reid,* Alison G. Montgomery, and James M. Musser

Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840

Received 9 June 2003/ Returned for modification 18 August 2003/ Accepted 26 November 2003

We have identified a Crp/Fnr-like transcriptional regulator of Streptococcus pyogenes that when inactivated attenuates virulence. The gene, named srv for streptococcal regulator of virulence, encodes a 240-amino-acid protein with 53% amino acid similarity to PrfA, a transcriptional activator of virulence in Listeria monocytogenes.

* Corresponding author. Present address: Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157. Phone: (406) 363-9398. Fax: (406) 363-9394. E-mail: sreid{at}wfubmc.edu.

Editor: V. J. DiRita

Infection and Immunity, March 2004, p. 1799-1803, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1799-1803.2004




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