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Infection and Immunity, March 2004, p. 1812-1816, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1812-1816.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Characterization of Cytolethal Distending Toxin Genes and Expression in Shiga Toxin-Producing Escherichia coli Strains of Non-O157 Serogroups

Institut für Hygiene, Universitätsklinikum Münster,¹ Institut für Infektiologie, Zentrum für Molekularbiologie der Entzündung (ZMBE), Universität Münster, 48149 Münster,² Robert-Koch Institut, Bereich Wernigerode, 38855 Wernigerode, Germany³

Received 29 August 2003/ Returned for modification 7 November 2003/ Accepted 11 December 2003

We identified cytolethal distending toxin and its gene (cdt) in 17 of 340 non-O157 Shiga toxin-producing Escherichia coli (STEC) strains (serotypes O73:H18, O91:H21, O113:H21, and O153:H18), all of which were eae negative. cdt is either chromosomal and homologous to cdt-V (serotypes O73:H18, O91:H21, and O113:H21) or plasmidborne and identical to cdt-III (serotype O153:H18). Among eae-negative STEC, cdt was associated with disease (P = 0.003).

Editor: A. D. O'Brien

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