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Infection and Immunity, March 2004, p. 1817-1819, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1817-1819.2004

Inclusion of CpG Adjuvant with Plasmid DNA Coding for NcGRA7 Improves Protection against Congenital Neosporosis

Mark Jenkins,^1* Carolyn Parker,¹ Wenbin Tuo,¹ Bryan Vinyard,² and J. P. Dubey¹

Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute,¹ Biometrics Consulting Unit, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland 20705²

Received 21 October 2003/ Returned for modification 23 November 2003/ Accepted 26 November 2003

The present study showed that incorporation of CpG adjuvant into plasmid DNA coding for NcGRA7 antigen resulted in a twofold increase in the level of protection against congenital transfer of Neospora caninum. The level of protection was considerably higher than that observed in pups born from dams immunized with nonrecombinant plasmid.

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* Corresponding author. Mailing address: Animal Parasitic Diseases Laboratory, ANRI, Agricultural Research Service, USDA, Beltsville, MD 20705. Phone: (301) 504-8300. Fax: (301) 504-5306. E-mail: mjenkins{at}anri.barc.usda.gov.

Editor: W. A. Petri, Jr.

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Infection and Immunity, March 2004, p. 1817-1819, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1817-1819.2004

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