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Infection and Immunity, March 2004, p. 1824-1827, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1824-1827.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Detection of Antibodies to Toxin-Coregulated Pili in Sera from Cholera Patients

Stephen R. Attridge,1* Gun Wallerström,2 Firdausi Qadri,3 and Ann-Mari Svennerholm2

Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia, Australia,1 Department of Medical Microbiology and Immunology, University of Göteborg, Göteborg, Sweden,2 Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh3

Received 30 June 2003/ Returned for modification 1 September 2003/ Accepted 25 November 2003

Monoclonal antibodies (MAbs) were prepared against toxin-coregulated pili (TCP) isolated from Vibrio cholerae O1 El Tor. Despite their limited bactericidal potential, two MAbs were able to mediate biotype-specific protection against experimental cholera in infant mice. These MAbs were used in immunoblotting studies to assess seroconversion to El Tor TCP following cholera. Clear anti-pilus responses were observed in five of nine patients.

* Corresponding author. Mailing address: Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia 5005, Australia. Phone: 61-8-83034150. Fax: 61-8-83037532. E-mail: stephen.attridge{at}adelaide.edu.au.

Editor: V. J. DiRita

Infection and Immunity, March 2004, p. 1824-1827, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1824-1827.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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