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Infection and Immunity, March 2004, p. 1828-1831, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1828-1831.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Heterozygous Toll-Like Receptor 2 Polymorphism Does Not Affect Lipoteichoic Acid-Induced Chemokine and Inflammatory Responses

Sonja von Aulock,1 Nicolas W. J. Schröder,2 Stephanie Traub,1 Katja Gueinzius,1 Eva Lorenz,3 Thomas Hartung,1 Ralf R. Schumann,2 and Corinna Hermann1*

Biochemical Pharmacology, University of Konstanz, 78457 Konstanz,1 Institute for Microbiology and Hygiene, University Medical Center Charité, 10117 Berlin, Germany,2 Department of Medicine, Section of Molecular Medicine and Infectious Diseases, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157-10423

Received 13 August 2003/ Returned for modification 24 September 2003/ Accepted 19 November 2003

While transfection of tlr2 conveyed responsiveness to lipoteichoic acid (LTA), the Arg753Gln polymorphic gene could not. LTA induced a stronger chemokine and anti-inflammatory response than lipopolysaccharides did. Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response.

* Corresponding author. Mailing address: Biochemical Pharmacology, University of Konstanz, 78457 Konstanz, Germany. Phone: 49-7531-884524. Fax: 49-7531-884156. E-mail: corinna.hermann{at}uni-konstanz.de.

Editor: T. R. Kozel

Infection and Immunity, March 2004, p. 1828-1831, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1828-1831.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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