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Infection and Immunity, March 2004, p. 1832-1836, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1832-1836.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Impacts of sarA and agr in Staphylococcus aureus Strain Newman on Fibronectin-Binding Protein A Gene Expression and Fibronectin Adherence Capacity In Vitro and in Experimental Infective Endocarditis

Yan-Qiong Xiong,1,2 Arnold S. Bayer,1,2* Michael R. Yeaman,1,2 Willem van Wamel,3 Adhar C. Manna,4 and Ambrose L. Cheung4

Department of Medicine, Division of Infectious Diseases, Harbor-UCLA Research and Education Institute, Torrance,1 Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California,2 Eijkman-Winkler Institute, UMC-Utrecht, Utrecht, The Netherlands,3 Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire4

Received 22 September 2003/ Returned for modification 23 October 2003/ Accepted 2 December 2003

We investigated the impacts of sarA and agr on fnbA expression and fibronectin-binding capacity in Staphylococcus aureus in vitro and in experimental endocarditis. Although sarA up-regulated and agr down-regulated both fnbA expression and fibronectin binding in vitro and in vivo, fnbA expression was positively regulated in the absence of both global regulators. Thus, additional regulatory loci contribute to fnbA regulation and fibronectin-binding capacities in S. aureus.

* Corresponding author. Mailing address: Division of Infectious Diseases, St. John's Cardiovascular Research Center, Harbor-UCLA Research and Education Institute, 1124 W. Carson St., Torrance, CA 90502. Phone: (310) 222-6422. Fax: (310) 782-2016. E-mail: bayer{at}humc.edu.

Editor: F. C. Fang

Infection and Immunity, March 2004, p. 1832-1836, Vol. 72, No. 3
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.3.1832-1836.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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