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Infection and Immunity, April 2004, p. 2379-2382, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2379-2382.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Hydrophobic Domain of the Mycobacterial Erp Protein Is Not Essential for the Virulence of Mycobacterium tuberculosis

Dana Kocíncová, Berit Sondén, Yann Bordat, Elisabeth Pivert, Leila de Mendonça-Lima,{dagger} Brigitte Gicquel, and Jean-Marc Reyrat*{ddagger}

Unité de Génétique Mycobactérienne, Institut Pasteur, Paris Cedex 15, F-75724, France

Received 26 September 2003/ Returned for modification 18 November 2003/ Accepted 1 December 2003

Erp (exported repetitive protein) is a member of a mycobacterium-specific family of extracellular proteins. A hydrophobic region that is localized at the C-terminal domain and that represents a quarter of the protein is highly conserved across species. Here we show that this hydrophobic region is not essential for restoring the virulence and tissue damage of an erp::aph mutant strain of M. tuberculosis as assessed by bacterial counts and lung histology analysis in a mouse model of tuberculosis.

* Corresponding author. Mailing address: Unité de Pathogénie des Infections Systémiques, UMR570, Faculté de Médecine Necker-Enfants Malades, 156 rue de Vaugirard, Paris Cedex 15, F-75730, France. Phone: (33 1) 40 61 53 79. Fax: (33 1) 40 61 56 77. E-mail: jmreyrat{at}necker.fr.

Editor: D. L. Burns

{dagger} Present address: Dept of Biochemistry and Molecular Biology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.

{ddagger} Present address: Unité de Pathogénie des Infections Systémiques, UMR 570, Paris Cedex 15, F-75730 France.

Infection and Immunity, April 2004, p. 2379-2382, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2379-2382.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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