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Infection and Immunity, April 2004, p. 2383-2385, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2383-2385.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Helicobacter pylori-Mediated Gastritis Induces Local Downregulation of Secretory Leukocyte Protease Inhibitor in the Antrum

Thomas Wex,1* Gerhard Treiber,1 Manfred Nilius,2 Michael Vieth,3 Albert Roessner,3 and Peter Malfertheiner1

Department of Gastroenterology, Hepatology and Infectious Diseases,1 Institute of Pathology, Otto-von-Guericke University, D-39120 Magdeburg,3 Vivotec Biomedical Technologies GmbH, D-39114 Magdeburg, Germany2

Received 1 August 2003/ Returned for modification 10 November 2003/ Accepted 22 December 2003

Helicobacter pylori-infected subjects exhibited a strong decline in antral secretory leukocyte protease inhibitor (SLPI) levels compared to H. pylori-negative subjects and subjects from whom H. pylori had been eradicated (P = 0.002). This reduction was specific for the antrum, whereas SLPI expression in corpus and duodenum was not affected. Antral SLPI levels were inversely correlated with inflammatory scores of antrum-predominant gastritis.

* Corresponding author. Mailing address: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. Phone: (49) 391-6713106. Fax: (49) 391-6713105. E-mail: thomas.wex{at}medizin.uni-magdeburg.de.

Editor: V. J. DiRita

Infection and Immunity, April 2004, p. 2383-2385, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2383-2385.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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