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Infection and Immunity, April 2004, p. 2386-2389, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2386-2389.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Tec1p-Independent Activation of a Hypha-Associated Candida albicans Virulence Gene during Infection

Peter Staib,1 Ayfer Binder,1 Marianne Kretschmar,2 Thomas Nichterlein,2 Klaus Schröppel,3 and Joachim Morschhäuser1*

Institut für Molekulare Infektionsbiologie, Universität Würzburg, D-97070 Würzburg,1 Institut für Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, D-68167 Mannheim,2 Institut für Klinische Mikrobiologie, Immunologie und Hygiene, Universität Erlangen, D-91054 Erlangen, Germany3

Received 27 October 2003/ Returned for modification 10 December 2003/ Accepted 22 December 2003

The Tec1p transcription factor is involved in the expression of hypha-specific genes in Candida albicans. Although the induction of the hypha-associated SAP5 gene by serum in vitro depends on Tec1p, deletion of all Tec1p binding site consensus sequences from the SAP5 promoter did not affect its activation. In two different animal models of candidiasis, the SAP5 promoter was induced even in a {Delta}tec1 deletion mutant, demonstrating that the requirement for Tec1p in gene expression in C. albicans depends on the environmental conditions within the host.

* Corresponding author. Mailing address: Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany. Phone: 49-931-31 21 52. Fax: 49-931-31 25 78. E-mail: joachim.morschhaeuser{at}mail.uni-wuerzburg.de.

Editor: T. R. Kozel

Infection and Immunity, April 2004, p. 2386-2389, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2386-2389.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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